Study on the effect of hyoscine-N-butylbromide suppository on pain and process of Labor

Labor is a painful process and one of the midwives duties is trying to reduce the intensity of labor pain, in which reduction of duration of clinical stages of labor has always been considered. The objective of this study was to evaluate the effect of hyoscine suppository on labor pain and process of labor. This double-blind clinical trial was down on 130 nulliparous pregnant women who referred to Ahvaz Sina hospital for parturition. A hyoscine suppository was given to case group and a placebo suppository was given to control group at beginning of active phase of labor, rectally. Then the labor pain mean, cervical dilatation and effacement progress, active phase and second stage duration and delivery type were recorded. The data were analyzed using T, Chi square and Fisher tests in 0.05 significant level in SPSS Version 15.0. were significant differences between mean of cervical dilatation and effacement 1 and 2 h after intervention in both groups [P<0.0001]. The active phase and second stage duration in case group were less than control group significantly [P=0.007]. Caesarean section rate in the case group was less than control group, but the difference was not significant [P=:0.07]. Labor pain intensity had not significant difference in both groups. There were no differences in fetal heart rate, maternal pulse rate and blood pressure and neonatal APGAR score between both groups. It seems that hyoscine suppository can be used to accelerate the process of labor and reduce duration of labor pain, effectively, but does not reduce labor pain

effect of hyoscine butylbromide on 1st stage of labour in term pregnancy

To determine the effect of hyoscoine butylbromide in shortening active phase of 1st stage of labour without adverse effects in mother and fetus. Randomized, double-blinded placebo controlled trail. Labour ward of PNS SHIFA hospital for duration of 06 months from 1st Jan 2008 to 30 June 2008. One hundred pregnant women both primigravida and multigravida in active phase of spontaneous labour [an active phase is defined as 3 cm or more cervical dilatation with regular uterine contraction] were included in the study. Either drug or placebo was given intravenously once the women entered active labour. Progress of labour was plotted on partogram student 't' test was applied for comparison for two groups. The duration of 1st stage of labour was main outcome. Secondary outcome measures included duration of second and third stages of labour, blood loss at delivery, and apgar score in neonates between the two groups. In patient receiving hyocscine butylbromid the active phase of 1st stage of labour was 194.8 +/- 87.3 mins as compared to placebo group where active phase 1st stage of labour was 282.3 +/- 92.3. There was significant difference in duration of active phase 1st stage in both groups of [87.5 mins], there was no significant change in duration of second and third stage of labour, no difference in blood loss, and apgar score in both groups. Hyoscine butybromide is effective significantly in reducing duration of 1st stage of labour in primigravida and multigravida with term pregnancy and it is not associated with any adverse out come in mother or neonate

Effect of Hyoscine-N-Butyl bromide [buscopan] in accelerating first stage of labor

To determine the effect of Hyoscine-N-Butyl Bromide [Busocpan] in accelerating first stage of labor and its relationship to the presence or absence of fetal membrane. The study was carried out between 1st May, 2007 and 3rd October, 2007 at Jidhafs Maternity Hospital in the Kingdomof Bahrain. A quasi-experimental prospective randomized control study was conducted on 92 primigravidas with single cephalic pregnancies who underwent spontaneous labor and who were not subjected for augmentation with any drug in active phase of labor. Sixty four patients were subjected to 40 mg intra-muscular injection of Busocpan and 28 acted as control. The rate of cervical dilatation was compared in both groups. The duration of fist stage of labor was 3.6 +/- 3.0 hours [mean +/- Standard deviation] for the Busocpan group and 4.7 +/- 2.9 hours [mean +/- SD.] for the control group. On comparing the mean of the duration of first stage of labor amongst different subgroups, it was found that the difference was only statistically significant in Buscopan group with absent membranes as compared to Busocpan group with intact membranes. Hyoscine-N-Butylbromide [Buscopan] was not effective in shortening the first stage of labor for primigravidas in comparison to control. However, Busocpan proved to be highly effective in shortening first stage of labor among patients with absent fetal membranes as compared to those who received Busocpan when their fetal membranes were present

[ effect of SP6 acupressure on length of labor]

Childbirth is a natural and physiologic process, but occasionally some problems such as prolonged labor phases occur, leading to medical interventions. The aim of this study was to evaluate the effect of acupressure on length of delivery time in pregnant women. This double blind clinical trial was performed in 2006 at Delivery Room of Shahid Fayyaz Bakhsh Hospital of Karaj, on 128 women in labor phase, with 3 cm cervical dilatation. This study was approved by the local committee of medical ethics. They randomly assigned to 30-minutes SP6 acupressure group [experimental] or SP6 touch group [control]. Length of the first and second stages of labor was compared between the two groups. Individual characteristics and examination results collected in a questionnaire and analyzed by descriptive statistics, frequency distribution tables, and Man whitney test. Length of the first stage of labor in SP6 acupressure group was significantly shorter than the one in SP6 touch group [p=0/027] and there was no significant difference in length of the second stage of labor between the two groups. These findings showed that SP6 acupressure could effectively reduces the Length of first stage of labor thus it may be used in active management of labor

Study of drotaverine on first stage of labour and pregnancy outcome.

A prospective randomised study of 200 women with spontaneous onset of labour was carried out in 100 women who were given 40mg of drotaverine hydrochloride intravenously at > or = 3cm dilatation of the cervix, the other 100 were taken as control. The effects of the drug on the progress and outcome of labour were noted. The mean durations of active phase of labour in primigravida and multigravida were 148.9 minutes and 99.5 minutes in drotaverine group whereas in control group were 331.6 minutes and 227.9 minutes respectively. It was concluded that drotaverine is highly effective in reducing the duration of active phase of labour by hastening cervical dilatation, more effective when given in more dilated cervix than with less dilatation and more effective in multigravida than in primigravida. There was no interference with uterine contractility and no increase in operative delivery. It reduces the incidence of traumatic postpartum haemorrhage by reducing the incidence of cervical tear. It is a safe drug for the mother as well as for the baby.